Models New
Hugging Face releases Carbon-X, an open 14.8-billion-parameter model that reads and writes DNA in plain-language chat
Published:
Hugging Face released Carbon-X on 22 October, an open model under the Apache 2.0 licence, built with Zhongguancun Academy and the Telethon Institute of Genetics and Medicine at the University of Naples Federico II. Its model card describes a 14.8-billion-parameter model, trained from Qwen3-14B on DNA sequences and ordinary text, that takes raw DNA inside a chat and answers in English, for example predicting whether a mutation is likely to be harmful.
Hugging Face reports that across five DNA benchmarks, covering variant-effect prediction, sequence understanding and next-base prediction, Carbon-X averages 66.7% with reasoning turned off: 27 points above the Qwen3-14B model it started from and ahead of the other open models it tested. Senior research scientist Lewis Tunstall told Business Insider the team wanted to give researchers tools that do not leave them dependent on a single external provider, and that viruses were left out of the training data to reduce the risk of misuse.
Caveat. Benchmarks are Hugging Face's own selection and were not independently reproduced. The model card says Carbon-X has not been clinically validated and should not be used for medical decisions, and that quality drops on long generated sequences.
Sources